Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation
Respiratory complex I is a multi-subunit membrane protein complex HydroRite / HydraPure Parts that reversibly couples NADH oxidation and ubiquinone reduction with proton translocation against transmembrane potential.Complex I from Escherichia coli is among the best functionally characterized complexes, but its structure remains unknown, hindering f